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KMID : 0811720070110000083
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Korean Journal of Physiology & Pharmacology
2007 Volume.11 No. 0 p.83 ~ p.0
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Role of System L Amino Acid Transporters LAT1 and LAT2 during Wound Healing Process
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Kim Chun-Sung
Jeong Moon-Jin
Kim Do-Kyung
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Abstract
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The continuous growth and proliferation of cells are essential for the wound healing process, and the amino acid transporters plays an important role in the continuous growing and proliferating cells. Among the amino acid transporters, the system L-type amino acid transporters, which are Na+-independent neutral amino acid transport system, are major route for providing living cells including tumor cells with neutral amino acids including several essential amino acids. In the present study, therefore, in order to elucidate the role of the system L-type amino acid transporters in the wound healing process of aged and young subjects, we investigated the expression of LAT1, LAT2 and their subunit 4F2hc in the skin healing process after artificial wounds of dorsal skin in the young and old rats. In young rats, until the last observation period, gradually and noticeable wound healing was detected, however, in old rats, wound healing was found to be greatly delayed. In young rats, the expression of LAT1 was increased rapidly on the day 1 after wound induction in comparison with the control group, on the other hand, in old rats, the expression of LAT1 mRNA after wound induction was not different from the control group. In young rats, the expression of LAT2 after the induction of wound was not different from the control group, and in old rats, the expression of LAT2 mRNA on the day 1 of wound induction was rapidly elevated in comparison with the control group. These results suggest that the LAT1 of which expression varies according to environmental changes plays an important role in the would healing process after cell injury in young rats and the LAT2 plays an important role in wound healing in old rats. This work was supported by grant No. R01-2005-000-10135-0 from the Basic Research Program of the Korea Science & Engineering Foundation.
Source: Korean Journal of Physiology & Pharmacology.2007 Oct;11(Suppl II):S80-S80
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KEYWORD
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Amino acids, System L amino acid transporters, Wound healing, Regeneration, Aging
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